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目的 研究氨甲喋呤的两种不同给药方法应用于输卵管妊娠的治疗效果.方法 选择2017年12月～2020年2月本科室接诊的输卵管妊娠病患56例,随机均分为两组,均采用氨甲喋呤治疗.其中,试验组采取经阴道超声引导下孕囊内注药法,对照组采取静脉推注法.对比两组包块消失时间等指标.结果 试验组治疗总有效率为96.43％,比对照组的75.00％ 高,P ＜ 0.05.试验组不良反应发生率为3.47％,比对照组的46.43％低,P ＜ 0.05.试验组的包块消失时间、血β-HCG 恢复正常时间与住院时间依次是(15.47±4.13)d、(17.68±0.92)d、(12.31±2.15)d,比对照组的(29.96±5.06)d、(20.58±0.69)d、(18.57±2.03)d 短,P ＜ 0.05.试验组治疗后sf-36 评分为(88.65±3.21)分,比对照组的(80.14±4.28)分高,P ＜ 0.05.结论 于输卵管妊娠中运用经阴道超声引导下孕囊中注射氨甲喋呤法,疗效显著,指标恢复迅速,不良反应少,且利于生活质量的改善.“,”Objective To study the therapeutic effects of two different administration methods of methotrexate applied to tubal pregnancy. Methods From December 2017 to February 2020, 56 patients with tubal pregnancy who were admitted to the undergraduate room were randomly divided into two groups, and both were treated with methotrexate. Among them, the trial group adopted transvaginal ultrasound guided intragestational sac injection. The control group took intravenous bolus injection. Compare indicators such as the disappearance time of the mass. Results The total effective rate of treatment in the experimental group was 96.43％, which was higher than 75.0％ in the control group, P＜0.05. The incidence of adverse reactions in the experimental group was 3.47％, which was lower than 46.43％ in the control group, P＜0.05. The mass disappearance time, blood β-HCG return to normal time, and hospitalization time in the experimental group were (15.47±4.13) d, (17.68±0.92) d, and (12.31±2.15) d, which were compared with (29.96±5.06) in the control group. d, (20.58±0.69)d,(18.57±2.03)d are short, P＜0.05. After treatment, the score of sf-36 in the experimental group was (88.65±3.21), which was higher than the score of(80.14±4.28) in the control group, P＜0.05. Conclusion The use of methotrexate injection into the gestational sac under the guidance of transvaginal ultrasound in tubal pregnancy has a significant effect, rapid recovery of indicators, few adverse reactions, and is beneficial to the improvement of quality of life.