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目的:研究姜黄素对链脲佐菌素(STZ)诱导C57BL/6小鼠血糖以及血脂的影响。方法:链脲佐菌素(STZ)合并高脂肪饮食诱导糖尿病小鼠模型,并随机分为正常组、模型组、阳性药组和姜黄素组,正常组、模型组灌胃0.5%CMC-Na,阳性组灌胃二甲双胍0.3 g/kg,姜黄素组灌胃姜黄素0.2 g/kg,连续给药8周。第8周最后一次给药后测定血糖、血脂、糖耐量、胰岛素耐量水平。结果:灌胃葡萄糖出现糖负荷以后,二甲双胍组血糖水平明显低于模型组(P<0.05);糖负荷后1 h时,姜黄素组血糖值明显较低(P<0.05)。注射胰岛素1 h后,姜黄素组血糖值明显低于模型组(P<0.05);二甲双胍组1 h后血糖明显低于模型组(P<0.05)。模型组血糖和糖化血红蛋白水平显著高于正常对照组,差异均具有显著性(P<0.05)。姜黄素组血清TG、LDL-C、HDL-C与模型组相比明显下降,均有显著差异(P<0.05),而TC水平降低不明显。结论:姜黄素可降低STZ所致糖尿病小鼠的血糖,增加糖耐量,提高小鼠机体胰岛素的敏感性,同时可纠正糖尿病小鼠脂代谢紊乱。
Objective: To study the effect of curcumin on blood glucose and blood lipid in streptozotocin (STZ) -induced C57BL / 6 mice. Methods: Diabetic mice were induced by streptozotocin (STZ) combined with high-fat diet and randomly divided into normal group, model group, positive drug group and curcumin group. Normal group and model group were given 0.5% CMC-Na , The positive group fed metformin 0.3 g / kg, curcumin group fed with curcumin 0.2 g / kg, continuous administration for 8 weeks. After the last administration in the 8th week, the blood glucose, blood lipid, glucose tolerance and insulin tolerance were measured. Results: The blood glucose level in the metformin group was significantly lower than that in the model group (P <0.05) after the glucose load was fed into the gavage glucose group. The blood glucose level in the curcumin group was significantly lower (P <0.05) at 1 h after the glucose load. Blood glucose of curcumin group was significantly lower than that of model group (P <0.05) 1 h after injection of insulin, blood glucose of metformin group was significantly lower than that of model group after 1 h (P <0.05). The levels of blood glucose and glycosylated hemoglobin in the model group were significantly higher than those in the normal control group (P <0.05). The levels of serum TG, LDL-C and HDL-C in curcumin group were significantly lower than those in the model group (P <0.05), while the TC levels were not significantly reduced. Conclusion: Curcumin can reduce the blood sugar of STZ-induced diabetic mice, increase the glucose tolerance, improve the insulin sensitivity of mice and correct the disorder of lipid metabolism in diabetic mice.