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目的检测许旺细胞标记物胶原原纤维酸性蛋白(GFAP)与肌上皮细胞标记物α-平滑肌肌动蛋白(α-SMA)在涎腺腺样囊性癌(ACC)中的表达情况,并探讨GFAP、α-SMA与ACC嗜神经侵袭的关系。方法用免疫组织化学、免疫荧光双标记及激光共聚焦显微镜技术检测GFAP蛋白与α-SMA蛋白在ACC组织中的表达。结果在ACC组织中,GFAP蛋白与α-SMA蛋白均有表达,二者在同一肿瘤性肌上皮样细胞胞质中共表达。结论ACC中肿瘤性肌上皮样细胞发生许旺细胞分化并侵袭神经可能是ACC嗜神经侵袭的组织病理学基础。
Objective To investigate the expression of glial fibrillary acidic protein (GFAP) and α-SMA in salivary adenoid cystic carcinoma (ACC) GFAP, α-SMA and ACC neuroinvasion. Methods Immunohistochemistry, double immunofluorescence staining and confocal laser scanning microscopy were used to detect the expression of GFAP and α-SMA in ACC tissues. Results In ACC tissues, both GFAP and α-SMA proteins were expressed, both of which were co-expressed in the cytoplasm of the same tumorous myoepithelial cells. Conclusions Differentiation of Schwann cells into tumorous myoepithelial cells in ACC and invasion of nerves may be the histopathological basis of ACC neuroinvasation.