论文部分内容阅读
目的:探讨乳腺癌扩增基因1(AIB1)在食管鳞癌组织中的表达及其临床意义。方法:用免疫组织化学法检测AIB1蛋白在60例食管鳞癌组织和30例癌旁正常食管黏膜组织中的表达,分析其与各临床病理因素之间的相关性。结果:60例食管鳞癌组织中AIB1蛋白的表达率为53.3%,30例癌旁正常黏膜组织中AIB1蛋白不表达或弱阳性表达,差异有统计学意义(P<0.01);食管鳞癌组织中AIB1蛋白的表达在不同肿瘤分化程度、淋巴结转移及临床分期间差异均有统计学意义(P<0.05~P<0.01),而在不同年龄、性别及浸润深度间表达差异均无统计学意义(P>0.05)。结论:AIB1蛋白在食管鳞癌组织中异常高表达,表明其可能影响食管鳞癌发生发展及浸润转移的进程。
Objective: To investigate the expression of breast cancer amplification gene 1 (AIB1) in esophageal squamous cell carcinoma and its clinical significance. Methods: The expression of AIB1 protein in 60 esophageal squamous cell carcinoma tissues and 30 adjacent normal esophageal mucosa tissues was detected by immunohistochemistry. The correlation between AIB1 protein and clinicopathological factors was analyzed. Results: The expression of AIB1 protein in 60 cases of esophageal squamous cell carcinoma was 53.3%, while the expression of AIB1 protein in 30 cases of adjacent normal mucosa tissues was not expressed or weakly positive (P <0.01); esophageal squamous cell carcinoma The expression of AIB1 protein in different stages of tumor differentiation, lymph node metastasis and clinical stage differences were statistically significant (P <0.05 ~ P <0.01), while in different age, gender and depth of invasion was no significant difference (P> 0.05). Conclusion: AIB1 protein is highly expressed in esophageal squamous cell carcinoma, indicating that it may affect the development, invasion and metastasis of esophageal squamous cell carcinoma.