在癫癎患者中,约有1／3为难治性癫癎患者,尽管有很多新的抗癫癎药物可以供临床医生选择,但是难治性癫癎的发病率并没有下降。应用两种抗癫癎药物而无法有效控制发作者,即使再加用其它抗癫癎药物也不能控制发作。有研究表明,癫癎患者,尤其是难治性癫癎患者,其生活质量和社会功能都受到严重的损害,包括低自卑心理、严重的抑郁、生 In epilepsy patients, about 1/3 of patients with refractory epilepsy, although there are many new anti-epileptic drugs for clinicians to choose, but the incidence of refractory epilepsy did not decline. The use of two anti-epileptic drugs can not effectively control the onset of the authors, even with the addition of other anti-epileptic drugs can not control the attack. Studies have shown that, in patients with epilepsy, especially refractory epilepsy, their quality of life and social functioning are severely impaired, including low self-esteem, severe depression,