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目的:研究和比较纳美芬和纳洛酮治疗急性酒精中毒的疗效。方法:将2010年4月2012年3月彭湃纪念医院急诊科就诊的急性酒精中毒患者196例随机分为研究组和对照组,兴奋期36例中纳入研究组17例,对照组19例,共济失调期121例中纳入研究组61例,对照组60例,昏睡昏迷期39例中纳入研究组19例,对照组20例,每组根据病情等级的不同给予不同剂量的纳美芬或纳洛酮治疗,比较两组治疗120 min后的疗效。结果:两组治疗兴奋期酒精中毒的疗效无显著性差异(P>0.05),研究组治疗共济失调期和昏睡昏迷期酒精中毒的疗效优于对照组(P均<0.05)。结论:纳美芬治疗共济失调期和昏睡昏迷期急性酒精中毒的疗效优于纳洛酮。
OBJECTIVE: To study and compare the efficacy of nalmefene and naloxone in the treatment of acute alcoholism. Methods: One hundred and sixty-six patients with acute alcoholism who were treated in emergency department of Peng Pai Memorial Hospital in April 2010 were randomly divided into study group and control group. Thirty-six patients in exclusion group were included in study group, 17 patients in control group and 19 patients in total 121 cases of economic disorders included in the study group of 61 cases, 60 cases in the control group, coma sleeping period in 39 cases were included in the study group 19 cases, control group of 20 cases, each group according to the severity of the different doses of nalmefene or Na Los ketone treatment, the treatment of 120 min after the two groups were compared. Results: There was no significant difference between the two groups in the treatment of alcoholism during excitement (P> 0.05). The efficacy of the study group in treating ataxia and drowsiness alcoholism was better than that in the control group (all P <0.05). CONCLUSIONS: Nalmefene is superior to naloxone in the treatment of acute alcoholism in ataxia and coma.