论文部分内容阅读
目的:探讨中国南方汉族人群中雌激素受体α(ERα)基因xbaI酶切多态性与冠心病危险因素的相关性。方法:应用聚合酶链反应-限制片断长度多态性(PCR-RFLP)分析的方法,检测236例冠心病(CAD)患者和117例对照组的ER基因型,并比较其与相关临床指标的关系。结果:ERα基因XbaI多态性存在XX、Xx、xx三种基因型,ERα、xbaI基因多态性与CAD患者年龄、性别、高血压、糖尿病、吸烟等CAD的经典危险因素及胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三脂等生化因素含量无关(P>0.05)。结论:在中国南方汉族人群中存在着ERα、XbaI基因多态性,与冠心病的危险因素无相关性。
Objective: To investigate the association between estrogen receptor α (ERα) gene xbaI polymorphism and risk factors of coronary heart disease in Han Chinese in southern China. Methods: The genotypes of ER in 236 patients with coronary heart disease (CAD) and 117 controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and compared with related clinical indicators relationship. Results: There were XX, Xx and XX genotypes in XbaI polymorphism of ERα gene. The polymorphisms of ERα and XbaI gene were associated with the classic risk factors of CAD such as age, sex, hypertension, diabetes and smoking in CAD patients and the risk factors of cholesterol, low density Lipoprotein, high density lipoprotein, triglyceride and other biochemical factors (P> 0.05). Conclusion: ERα and XbaI polymorphisms exist in Han population of southern China and have no correlation with risk factors of coronary heart disease.