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目的分析血清中可溶性主要组织相容性复合体Ⅰ类链相关蛋白A(Soluble major histocompatibility complexclass I chain-related protein A,sMICA)与妇科恶性肿瘤的相关性。方法应用ELISA法检测59例确诊为妇科恶性肿瘤患者和98名健康对照者血清中sMICA的水平,应用ROC曲线对检测结果进行分析与评价。结果病例组患者血清中sMICA平均水平[(1.04±1.33)ng/ml]明显高于健康对照组[(0.29±0.30)ng/ml)],且差异有统计学意义(P<0.000 1)。ROC曲线下面积为0.816,sMICA的临床诊断界点为0.302 ng/ml。结论血清中sMICA水平与妇科恶性肿瘤的发生密切相关,有望作为临床妇科肿瘤诊断的一种新型肿瘤标志物。
Objective To analyze the correlation between serum soluble major histocompatibility complexclass I chain-related protein A (sMICA) and gynecologic malignancies. Methods The levels of sMICA in serum of 59 patients diagnosed as gynecologic malignant tumors and 98 healthy controls were detected by ELISA. The results of ROC curves were analyzed and evaluated. Results The average level of sMICA in serum of patients in the case group [(1.04 ± 1.33) ng / ml] was significantly higher than that in the healthy controls [(0.29 ± 0.30) ng / ml)], and the difference was statistically significant (P <0.0001). The area under the ROC curve was 0.816 and the clinical diagnostic cutoff for sMICA was 0.302 ng / ml. Conclusion The level of sMICA in serum is closely related to the occurrence of gynecological malignancies, which is expected to be a new tumor marker for the diagnosis of clinical gynecologic tumors.