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目的:探讨早期联合干预对脑损伤早产儿智能及运动发育的影响。方法:80例存在脑损伤的早产儿随机分为干预组与对照组,每组各40例,对照组给予常规治疗与保健指导,干预组在此基础上联合神经节苷脂治疗与早期康复训练,定期随访两年,观察比较患儿纠正胎龄40周时神经行为评分(NBNA),智力及运动发育情况。结果:干预组患儿纠正胎龄40周NBNA评分为33.04±1.12,对照组NBNA评分为30.95±0.88,两组间差异有统计学意义(P<0.05);干预组MDI与PDI指数分别于9月龄始和6月龄始显著高于对照组(P<0.01或0.05);1岁时进行Gesell智力发育检查,干预组大运动、精细动作、适应性、语言、个人-社会交往等五个能区情况均明显好于对照组(P<0.01);干预组17.5%的后遗症发生率显著低于对照组32.5%的发生率(P<0.01)。结论:联合早期干预治疗可有效促进脑损伤早产儿神经系统功能修复,改善智能及运动发育,减少后遗症发生。
Objective: To explore the effect of early combined intervention on intelligence and motor development in premature infants with brain injury. Methods: Eighty premature infants with brain injury were randomly divided into intervention group and control group, 40 cases in each group. The control group was given routine treatment and health guidance. On the basis of this, the intervention group was treated with ganglioside and early rehabilitation training , Followed up for two years on a regular basis. Observe and compare the neurobehavioral score (NBNA), intelligence and motor development in children with gestational age of 40 weeks. Results: The NBNA score corrected for gestational age at 40 weeks was 33.04 ± 1.12 in the intervention group and NBNA score in the control group was 30.95 ± 0.88, with significant difference between the two groups (P <0.05). The intervention group’s MDI and PDI index were 9 Month old and 6 months old were significantly higher than those in the control group (P <0.01 or 0.05). At the age of 1, Gesell’s mental development was examined. Five intervention groups including large exercise, fine motor, adaptability, language, personal-social interaction (P <0.01). The incidence of sequelae in 17.5% of the intervention group was significantly lower than that of the control group (32.5%) (P <0.01). Conclusion: The combined treatment of early intervention can effectively promote the repair of nervous system function in premature infants with brain injury, improve intelligence and motor development, and reduce the occurrence of sequelae.