放射线可引起细胞DNA损伤,导致肿瘤细胞周期阻滞,并引导细胞凋亡。野生型p53(WTp53)可使细胞阻滞于G2/M期,产生凋亡和细胞增殖抑制作用,而有利于发挥放疗敏感性,因此基因的改变尤其是抑癌基因p53对放疗的疗效起决定性的调控作用。而p53基因的变异(MTp53)将失去这种功能,这是产 Radiation can cause DNA damage in cells, leading to tumor cell cycle arrest and apoptosis. Wild-type p53 (WTp53) can block cells in G2 / M phase, resulting in apoptosis and cell proliferation inhibition, which is conducive to play a radiosensitivity, and therefore gene changes, especially tumor suppressor gene p53 on radiotherapy efficacy decisive The regulatory role. The p53 gene mutation (MTp53) will lose this function, which is produced