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目的探讨雷贝拉唑联合克拉霉素与阿莫西林治疗良性胃溃疡患者的临床疗效。方法选取2013年4月至2016年4月山东省东营乐安糖尿病肾病医院收治的100例良性胃溃疡患者作为研究对象,按随机数字表法将其分为对照组与研究组,每组50例。对照组患者给予阿莫西林、克拉霉素、果胶铋,研究组患者采用雷贝拉唑联合克拉霉素、阿莫西林进行治疗。比较两组患者临床疗效、腹痛缓解时间、腹痛缓解情况、幽门螺杆菌(Hp)转阴率及不良反应发生情况。结果研究组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);研究组患者腹痛缓解时间为(2.4±0.5)d,明显短于对照组的(5.2±0.8)d,差异有统计学意义(t=20.5762,P=0.0000<0.05);研究组患者腹痛缓解率显著高于对照组,差异有统计学意义(P<0.05);研究组患者Hp转阴率明显高于对照组,差异有统计学意义(χ~2=5.0051,P=0.0252<0.05)。结论雷贝拉唑联合克拉霉素与阿莫西林治疗良性胃溃疡患者临床疗效显著,可有效缩短腹痛时间,提高Hp转阴率,且安全性较高。
Objective To investigate the clinical efficacy of rabeprazole combined with clarithromycin and amoxicillin in the treatment of patients with benign gastric ulcer. Methods 100 patients with benign gastric ulcer admitted to the Diabetes Nephropathy Hospital of Dongying, Dongying, Shandong Province from April 2013 to April 2016 were selected as the research objects. According to the random number table, they were divided into control group and study group, 50 cases in each group . The patients in the control group were given amoxicillin, clarithromycin and bismuth pectin. The patients in the study group were treated with rabeprazole combined with clarithromycin and amoxicillin. The clinical curative effect, the relief time of abdominal pain, the relief of abdominal pain, the negative rate of Helicobacter pylori (Hp) and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in study group was significantly higher than that in control group (P <0.05). The relief time of abdominal pain in study group was (2.4 ± 0.5) d, which was significantly shorter than that of control group (5.2 ± 0.8 ) d, the difference was statistically significant (t = 20.5762, P = 0.0000 <0.05); study group patients with remission rate was significantly higher than the control group, the difference was statistically significant (P <0.05); study group patients Hp negative rate Was significantly higher than the control group, the difference was statistically significant (χ ~ 2 = 5.0051, P = 0.0252 <0.05). Conclusion Rabeprazole combined with clarithromycin and amoxicillin in the treatment of patients with benign gastric ulcer clinical significant effect, which can effectively shorten the time of abdominal pain, improve Hp negative rate, and high safety.