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目的:探讨高体重指数支气管哮喘患者血清中IL-8、IL-10及INF-γ的变化及临床意义。方法:选择高体重指数支气管哮喘患者(36例)、正常体重指数支气管哮喘患者(32例)以及健康人(32例),采用双抗体夹心ELISA法检测其急性发作期和缓解期血清中IL-8、IL-10和INF-γ的水平。结果:①高体重指数支气管哮喘组与正常体重指数支气管哮喘组急性发作期血清中IL-8水平显著高于缓解期以及对照组的水平(P<0.05)。②在缓解期,高体重指数支气管哮喘组血清中IL-8水平仍高于正常体重指数支气管哮喘组和对照组的水平(P<0.05)。③在急性发作期,高体重指数支气管哮喘组和正常体重指数支气管哮喘组血清中IL-10水平均显著低于其在缓解期及对照组的水平(P<0.05)。④三组间血清INF-γ水平在急性期与缓解期均无明显差异(P>0.05)。结论:血清中IL-8是高体重指数支气管哮喘患者发病过程中的重要炎症因子,并且始终参与其中。IL-10可能是支气管哮喘的抑炎因子,其缺乏可能是导致哮喘患者急性发作的因素之一。
Objective: To investigate the changes of serum IL-8, IL-10 and INF-γ in patients with high body mass index bronchial asthma and its clinical significance. Methods: 36 patients with high body mass index of bronchial asthma, 32 patients with normal body mass index of bronchial asthma and 32 healthy subjects were enrolled in this study. Serum IL- 8, IL-10 and INF-γ levels. Results: ① The level of IL-8 in the serum of patients with high body mass index bronchial asthma group and normal body mass index bronchial asthma group was significantly higher than that of remission group and control group (P <0.05). ② In the remission period, serum IL-8 levels in high body mass index bronchial asthma group were still higher than those in normal body mass index bronchial asthma group and control group (P <0.05). (3) IL-10 levels in serum of patients with high body mass index bronchial asthma group and normal body mass index bronchial asthma group were significantly lower than those in remission stage and control group (P <0.05). ④ There was no significant difference in serum INF-γ levels between the three groups in acute phase and remission (P> 0.05). Conclusion: Serum IL-8 is an important inflammatory factor in the pathogenesis of high body mass index bronchial asthma patients, and always participate in them. IL-10 may be an anti-inflammatory factor in bronchial asthma. The lack of IL-10 may be one of the factors leading to the acute attack of asthma.