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目的:观察在常规疗法基础上采用醒脑静注射液联合康复护理治疗中度阿尔茨海默病患者的疗效及安全性。方法:选取91例中度阿尔茨海默病患者作为研究对象,随机分入观察组和对照组。对照组45例采用常规治疗和护理,观察组46例在对照组基础上加用醒脑静注射液联合康复护理进行治疗。观察比较2组患者治疗1年后的简易精神状态评价(MMSE)量表、日常生活能力量表(ADL)评分改善情况和药物不良反应情况。结果:治疗1年后,2组MMSE量表评分均较治疗前提高(P<0.01),观察组评分高于对照组,差异均有统计学意义(P<0.01);2组ADL评分均较治疗前提高(P<0.05,P<0.01),观察组评分低于对照组,差异有统计学意义(P<0.05)。2组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规疗法基础上应用醒脑静注射液联合康复护理对中度AD患者进行干预,可以显著改善患者的精神状态,提高日常生活能力,同时不良反应发生率低,是一种安全有效的治疗方法。
Objective: To observe the efficacy and safety of Xingnaojing injection combined with rehabilitation nursing on patients with moderate Alzheimer’s disease on the basis of conventional therapy. Methods: Ninety-one patients with moderate Alzheimer’s disease were selected as study subjects and randomly divided into observation group and control group. Control group, 45 cases of conventional treatment and care, the observation group of 46 patients in the control group on the basis of plus xingnaojing injection combined with rehabilitation nursing for treatment. The MMSE scale, ADL score and adverse drug reactions (ADR) scores were compared between the two groups after one year of treatment. Results: After 1 year of treatment, the score of MMSE in both groups was significantly higher than that before treatment (P <0.01), and the score in observation group was higher than that in control group (P <0.01). The ADL scores of two groups were significantly higher than those before treatment (P <0.05, P <0.01). The score of the observation group was lower than that of the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P> 0.05). Conclusion: It is safe and effective to use Xingnaojing injection combined with rehabilitation nursing to treat moderate AD patients on the basis of routine therapy, which can significantly improve the mental status of patients and improve their daily living ability, while the incidence of adverse reactions is low treatment method.