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目的:探讨门诊抗菌药物不合理使用致不良反应的原因及方法,为临床合理用药提供参考。方法:随机抽取2010年2月～2012年2月间我院儿科门诊处方2560张,分析评价抗菌药物用药的不合理使用情况及不良反应情况。结果:我院儿科门诊抗菌药物不合理使用处方占抽查处方的12.1%,主要为克林霉素类、头孢菌素类及青霉素类用药。出现抗菌药物不良反应11例,不良反应率为7.0%。原因主要为给药时间不合理、超范围或无指征使用抗生素药、联合用药不合理及重复用药几方面。结论:我院儿科门诊抗菌药物使用仍存在一定问题,建立、完善抗菌药物相关制度,进一步规范医务人员的用药行为,确保临床抗菌药物使用的安全、有效、规范、经济、合理,减少不良反应事件的发生率十分必要。
OBJECTIVE: To explore the causes and methods of adverse reactions caused by unreasonable use of outpatient antibacterial drugs, and to provide reference for clinical rational drug use. Methods: A total of 2560 pediatric outpatient prescriptions in our hospital from February 2010 to February 2012 were randomly selected to analyze and evaluate the unreasonable use of antimicrobial drugs and adverse reactions. Results: The irrational use of antibacterials in pediatric outpatient department in our hospital accounted for 12.1% of the randomized prescriptions, mainly clindamycins, cephalosporins and penicillins. There were 11 cases of adverse reactions of antibiotics, the adverse reaction rate was 7.0%. The main reason for the administration time is unreasonable, over-range or no indication of the use of antibiotics, combination of unreasonable and repeated medication several aspects. Conclusion: The use of antibacterials in pediatric outpatient clinics in our hospital still has some problems. The system of antibacterial drugs is established and perfected to further regulate the medication behavior of medical staffs and ensure the safe, effective, standardized, economical and reasonable clinical use of antibacterials and the reduction of adverse reaction events The incidence is very necessary.