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目的探讨正常妊娠不同时期胎盘组织中chemerin水平变化,及其与妊娠进展的关系。方法选取妊娠早期孕妇20例,妊娠中期孕妇15例,妊娠晚期孕妇30例,采用免疫组织化学技术和实时定量PCR技术检测各妊娠组胎盘绒毛组织中chemerin水平。结果 chemerin阳性染色颗粒主要表达于胎盘组织中的合体滋养细胞及细胞滋养层细胞胞质中,各期均有不同程度的表达,妊娠晚期近临产组chemerin表达水平与早、中期妊娠组相比明显升高,差异具有统计学意义(P<0.05)。结论 chemerin可能在维持妊娠期间母胎免疫应答中起重要的作用。
Objective To investigate the changes of chemerin levels in placenta at different stages of normal pregnancy and its relationship with the progress of pregnancy. Methods Twenty pregnant women in the first trimester, 15 pregnant women in the second trimester, and 30 pregnant women in the third trimester of pregnancy were enrolled in this study. The chemerin levels in placenta villi of each pregnancy group were detected by immunohistochemistry and real-time quantitative PCR. Results Chemerin staining was mainly expressed in the syncytiotrophoblasts and cytotrophoblast cytoplasm of placenta, with different expression levels in all stages. The expression of chemerin in the late trimester of pregnancy was significantly higher than that of the early and middle trimester pregnancies Increased, the difference was statistically significant (P <0.05). Conclusion Chemerin may play an important role in maintaining the immune response of the fetus during pregnancy.