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目的分析头孢呋辛致过敏性休克的原因,包括宿主因素和不合理用药因素。方法回顾性分析2011~2016年因使用头孢呋辛(肠道或非肠道给药)致过敏性休克的文献。结果头孢呋辛所致过敏性休克主要发生在给药后的10min内(41.18%),将一日剂量一次给予患者是导致过敏性休克的主要原因(38.46%)。结论头孢呋辛仍是安全的抗菌药物,在使用时注意宿主因素及合理使用可减少过敏性休克的发生。
Objective To analyze the causes of anaphylactic shock caused by cefuroxime, including host factors and irrational medication factors. Methods A retrospective review of the literature from 2011 to 2016 on the use of cefuroxime (either enterally or parenterally) to cause anaphylactic shock was performed. Results The incidence of anaphylactic shock of cefuroxime was mainly within 10 minutes (41.18%) after administration. One-time daily dose of anaphylactic shock was the main cause of anaphylactic shock (38.46%). Conclusions Cefuroxime is still a safe antimicrobial agent. Attention should be paid to the factors of the host and rational use can reduce the occurrence of anaphylactic shock.