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目的:探讨男男性行为者(MSM)HIV暴露前预防用药(Pr EP)接受意愿、服药方式的选择及其影响因素。方法:采用滚雪球法招募乌鲁木齐市MSM,利用问卷调查形式,收集该人群自我保护意识、服药所担心的问题、Pr EP接受意愿及服药方式选择情况,再根据其选择的服药方式发放Pr EP药物,进行干预。结果:379名合格研究对象中有68.3%表示愿意接受Pr EP,在这些人中33.2%选择每天服药,66.8%选择性行为前后服药。Logistic回归分析显示,影响Pr EP可接受性的因素为:性行为扮演的角色、是否得过性病、是否做过艾滋病检测、安全套使用频率,即女性角色(vs男性角色,OR=0.34,95%CI:0.19~0.60)、得过性病(vs没得过,OR=0.20,95%CI:0.07~0.56)者容易接受Pr EP;没做过艾滋病检测(vs做过检测,OR=2.06,95%CI:1.11~3.81)、安全套的使用频率高(vs使用频率低,OR=1.46,95%CI:1.01~2.09)者相对不容易接受Pr EP。影响Pr EP服药方式选择的因素为:性行为扮演的角色、是否得过性病、文化程度、就业情况、担心因服药而受歧视,即女性角色(vs男性角色,OR=4.00,95%CI:1.77~9.02)、得过性病(vs没得过,OR=5.66,95%CI:2.37~13.54)者容易选择每天服药;文化程度低(vs文化程度高,OR=0.35,95%CI:0.17~0.72)、学生(vs在业人员,OR=0.06,95%CI:0.01~0.32)、担心因服药而受他人的歧视(vs不担心歧视,OR=0.30,95%CI:0.18~0.49)者容易选择性行为前后服药。结论:增强该人群的自我保护意识,保证服药的方便性和隐蔽性,可以提高MSM人群Pr EP可接受性及鼓励更多人选择每天服药的方式。
Objective: To investigate the willingness of pre-exposure prophylaxis (PrEP) for HIV-positive men and to choose the mode of medication and its influencing factors in men who have sex with men (MSM). Methods: The snowball method was used to recruit MSM in Urumqi. The survey questionnaire was used to collect the awareness of self-protection, the problems of taking medication, the willingness of Pr EP to accept and the choice of medication mode, and then to distribute Pr EP drugs according to their choice of medication. Intervene. RESULTS: Of the 379 eligible subjects, 68.3% said they were willing to receive Pr EP, with 33.2% of those taking the medication daily and 66.8% of the time before and after selective action. Logistic regression analysis showed that the factors influencing the acceptability of Pr EP were: the role of sexual behavior, sexually transmitted diseases, HIV / AIDS testing, the frequency of condom use, that is, the female role (vs male role, OR = 0.34, 95% CI: 0.19 ~ 0.60), who had sexually transmitted diseases (vs not available, OR = 0.20,95% CI: 0.07 ~ 0.56) were susceptible to PrEP; did not do AIDS testing (vs done testing, OR = 2.06,95 % CI: 1.11-3.81). The high frequency of condom use (vs low frequency of use, OR = 1.46, 95% CI: 1.01-2.09) was relatively unacceptable for Pr EP. The factors influencing the choice of Pr EP medication were: sexual role, sexuality, education, employment, fear of discrimination due to medication, ie, female role (vs male role, OR = 4.00, 95% CI: 1.77 ~ 9.02), who had sexually transmitted diseases (vs never achieved, OR = 5.66, 95% CI: 2.37 ~ 13.54) ~ 0.72), students who were unemployed (OR = 0.06, 95% CI: 0.01-0.32) were worried about being discriminated against others because of medication (vs not worried about discrimination, OR = 0.30, 95% CI: 0.18-0.49) Easy to choose sexual behavior before and after taking medication. CONCLUSIONS: Enhancing this population’s awareness of self-protection and ensuring the convenience and concealment of medication can improve the acceptability of Pr EP in MSM population and encourage more people to choose the way they take medicine daily.