论文部分内容阅读
目的儿童抗癫痫药物的血药浓度测定可提高疗效，减少毒副作用，指导临床合理使用抗癫痫药物。方法对单种药和两药联用的８６例癫痫患儿，用荧光偏振免疫法（ＦＴＩＡ）和稳态血药浓度一点法监测血药浓度并进行疗效分析。结果单用一药能控制症状不宜并用两药；必须两药联用时应注意药物相互作用。结论儿童的抗癫痫药物的血药浓度监测，能及早发现不易觉察的中毒，并结合疗效调整给药剂量与方法。
Objective Children antiepileptic drug plasma concentration determination can improve the curative effect, reduce the side effects, and guide clinical rational use of antiepileptic drugs. Methods Eighty-six children with epilepsy who were combined with single drug and two drugs were enrolled in this study. Plasma concentration was monitored by fluorescence polarization immunoassay (FTIA) and steady-state plasma concentration, and the therapeutic effect was analyzed. Results with a single drug can control the symptoms should not be combined with two drugs; must be combined with the two drugs should pay attention to drug interactions. Conclusion The monitoring of plasma concentration of antiepileptic drugs in children can detect the unidentified poisoning as soon as possible and adjust the dosage and method of treatment according to the curative effect.