目的 探析氨磺必利片在精神分裂症急性发作患者中的治疗效果。方法 选取本院2017年4月至2018年12月诊治的精神分裂症急性发作患者118例为对象，采用随机数字表法进行分组，对照组应用奥氮平治疗，观察组应用氨磺必利治疗，对比两组的治疗效果。结果 观察组患者治疗前、治疗2周后、治疗4周后、治疗8周后的阳性与阴性症状量表（PANSS）的阳性症状评分、阴性症状评分、一般精神病理症状评分和总分与对照组患者对比，差异均无统计学意义，P＞0.05；观察组治疗8周后的总有效率（94.92%）与对照组的总有效率（91.5“,”Objective To explore the therapeutic effect of amipride tablets in patients with acute episode of schizophrenia. Methods A total of 118 patients with acute episode of schizophrenia diagnosed and treated in our hospital from April 2017 to December 2018 were randomly divided into two groups: the control group was treated with olanzapine， the observation group was treated with amesulide， and the effect of the two groups was compared. Results There were no statistical differences in positive symptom score， negative symptom score， general psychopathological symptom score and total score between the observation group and the control group before treatment， 2 weeks after treatment， 4 weeks after treatment， and 8 weeks after treatment (P＞0.05). There was no significant difference in the total effective rate between the observation group and the control group after 8 weeks treatment (P＞0.05)， but the incidence of adverse reactions in the observation group (8.47%) was lower than that in the control group (27.12%)， the difference was statistically significant (P＜0.05).Conclusion Amsulpride and olanzapine are effective in the treatment of schizophrenia in acute attack， both of which can promote the remission of clinical symptoms， but the adverse reactions of amipride are less， which is beneficial to improve the drug compliance of patients.