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氧是维持机体代谢和内环境稳态的基本条件,高原地区的低张性缺氧是畜禽呼吸道狭窄、脑膜炎、呼吸中枢麻痹等重大疾病发生发展的主要原因,严重制约着畜禽动物的生产性能。低氧适应分子机制的研究对于疾病治疗、药物开发、畜牧业发展具有重要影响。随着免疫组化、实时定量PCR、基因芯片、基因组测序等分子生物技术的应用,高原动物低氧适应性的分子调控机制也得到了进一步认识。
Oxygen is the basic condition for maintaining metabolism and homeostasis in the body. Hypobaric hypoxia in the plateau is the main reason for the development of major diseases such as respiratory tract stenosis, meningitis and respiratory paralysis in mammals, which severely restricts the development of livestock and poultry Production performance. Hypoxic adaptation molecular mechanism of research for disease treatment, drug development, animal husbandry development has a significant impact. With the application of molecular biology techniques such as immunohistochemistry, real-time quantitative PCR, gene chip and genome sequencing, the molecular regulation mechanism of hypoxia adaptation in plateau fauna has been further recognized.