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目的：探讨马肝汤对肝细胞的修复作用。方法：将４０ 只小鼠随机等分为盐水对照组、药物对照组、损伤组和治疗组，损伤组和治疗组小鼠在第１、５ 天注射ＣＣｌ４ 制成肝损伤模型，药物对照组和治疗组每天皮下注射马肝汤０．１ ｍ ｌ／１６ ｇ，连续７ ｄ，各组小鼠均于第８天处死，取肝脏作电镜观察。结果：ＣＣｌ４ 肝损伤小鼠肝细胞质中含有大量的脂滴，微绒毛明显减少、肿胀，线粒体肿胀变性，血窦普遍变窄，多有灶性成堆红细胞瘀积。经马肝汤治疗后，肝细胞无明显肿胀，肝细胞质中脂滴明显减少，血窦相对增宽，无红细胞瘀积现象，肝细胞窦面微绒毛明显增多。结论：马肝汤对ＣＣｌ４ 肝损伤小鼠肝细胞具有保护、修复和再生作用
Objective: To investigate the effect of Magan Decoction on hepatocyte repair. Methods: Forty mice were randomly divided into saline control group, drug control group, injury group, and treatment group. Injury group and treatment group mice were injected with CCl4 on the first and fifth days to make a liver injury model. The treatment group was injected subcutaneously with 0.1 ml/16 g of Magan Decoction every day for 7 days. All groups of mice were sacrificed on the 8th day and the livers were taken for electron microscopy. RESULTS: The hepatic cytoplasm of CCl4 liver injury mice contained a large number of lipid droplets. The microvilli were significantly reduced, swollen, the mitochondria were swollen and degenerated, the sinusoids were generally narrowed, and there were many focal hematopoietic piles. After treatment with Magan Decoction, there was no obvious swelling of hepatocytes, the lipid droplets in hepatic cytoplasm were significantly reduced, the sinusoids were relatively widened, there was no evidence of red blood cell hoarding, and microvilli on the sinusoidal surface of liver cells increased significantly. Conclusion: Ma Gan Decoction has protective, repairing and regenerating effects on liver cells of CCl4 liver-injured mice