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本文测定了５０例女性ＳＬＥ患者血清雌二醇、睾酮水平，其中３２例检测了其ＰＢＭＣ产生ＩＬ－２活性，２３例检测了其ＰＢＭＣ产生γ－干扰素活性。结果表明：患者血清雌二醇升高，睾酮下降（Ｐ＜０．０１），其ＰＢＭＣ产生ＩＬ－２活性降低，且初发患者血清雌二醇水平与其ＰＢＭＣ产生ＩＬ－２活性呈直线负相关。为进一步阐明ＳＬＥ发病机理提供了线索。
In this study, serum estradiol and testosterone levels were measured in 50 women with SLE. Of these, 32 were tested for IL-2 production by their PBMCs and 23 were tested for IFN-γ production by PBMCs. The results showed that serum estradiol and testosterone were decreased (P <0.01), and the activity of IL-2 in PBMC was decreased. The serum estradiol level in newly diagnosed patients was negatively correlated with IL-2 activity in PBMC . It provides clues to further elucidate the pathogenesis of SLE.