目的探讨氨氯地平片联合瑞舒伐他汀钙片治疗高血压合并冠心病的疗效及安全性。方法 50例高血压合并冠心病患者,采用电脑随机抽签的方式分为对照组与观察组,每组25例。对照组采用硝苯地平控释片联合厄贝沙坦氢氯噻嗪片进行治疗,观察组采用氨氯地平片联合瑞舒伐他汀钙片进行治疗,对比两组患者治疗效果。结果观察组总有效率96.00%优于对照组68.00%,差异具有统计学意义(P<0.05)。观察组治疗后舒张压与收缩压分别为(81.9±4.7)、(124.5±10.1)mm Hg(1 mm Hg=0.133 kPa),优于对照组的(93.8±5.1)、(136.8±11.3)mm Hg,差异均具有统计学意义(P<0.05)。治疗期间,观察组恶心1例,腹泻1例,不良反应发生率8.00%,在调整后均缓解;对照组头痛1例,恶心1例,不良反应发生率8.00%,在调整后均缓解;两组不良反应情况对比差异无统计学意义(P>0.05)。结论在高血压合并冠心病的治疗中,采用氨氯地平片联合瑞舒伐他汀钙片效果更加显著,能够有效降低血压,且不良反应少,具一定安全性,值得推广。 Objective To investigate the efficacy and safety of amlodipine combined with rosuvastatin calcium in the treatment of patients with hypertension and coronary heart disease. Methods Fifty patients with hypertension and coronary heart disease were randomly divided into control group and observation group with 25 randomized controlled trials. The control group was treated with nifedipine controlled release tablets combined with irbesartan hydrochlorothiazide tablets. The observation group was treated with amlodipine tablets and rosuvastatin calcium tablets, and the treatment effect was compared between the two groups. Results The total effective rate in observation group was 96.00%, which was significantly higher than that in control group (68.00%) (P <0.05). The diastolic blood pressure and systolic blood pressure in the observation group were (81.9 ± 4.7), (124.5 ± 10.1) mm Hg (1 mm Hg = 0.133 kPa) respectively, which were significantly higher than those in the control group (93.8 ± 5.1), (136.8 ± 11.3) mm Hg, the differences were statistically significant (P <0.05). During the treatment, one case of nausea and one case of diarrhea were observed in the observation group and the rate of adverse reactions was 8.00%. All patients in the observation group were relieved after adjustment. One case of headache in control group, nausea and one case of nausea and 8.00% of adverse reactions were relieved after adjustment. There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion In the treatment of hypertension with coronary heart disease, the combination of amlodipine tablets and rosuvastatin calcium tablets is more effective, which can effectively lower blood pressure and less adverse reactions, with a certain safety and worth promoting.