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目的观察血浆P-选择素(P-selectin)及血清一氧化氮(NO)水平在急性冠脉综合征(ACS)患者中的变化,探讨其与急性冠脉综合征的关系。方法用ELISA方法测定60例急性冠脉综合征患者-急性心肌梗死(AMI)、不稳定型心绞痛(UAP)各30例,30例稳定型心绞痛患者(SAP)、30例体检健康者血浆P-selectin及血清NO水平。结果⑴急性冠脉综合征患者血浆P-selectin水平较稳定型心绞痛患者及健康对照组明显升高(P<0.01),⑵急性冠脉综合征患者血清NO水平较对照组明显降低(P<0.01)。⑶血清NO与血浆P-selectin水平成负相关(P<0.01),与高密度脂蛋白胆固醇(HDL-C)水平成正相关(P<0.05)。结论血浆P-selectin及血清NO水平对急性冠脉综合征的诊断有指导意义。
Objective To observe the changes of plasma P-selectin and serum nitric oxide (NO) levels in patients with acute coronary syndrome (ACS) and to explore its relationship with acute coronary syndrome. Methods Thirty patients with acute coronary syndrome (AMI), 30 with unstable angina pectoris (UAP), 30 with stable angina pectoris (SAP) and 30 with normal physical examination were enrolled in this study. selectin and serum NO levels. Results (1) Plasma P-selectin levels in patients with acute coronary syndrome were significantly higher than those in patients with stable angina and healthy controls (P <0.01). (2) Serum NO levels in patients with acute coronary syndrome were significantly lower than those in controls ). Serum NO was negatively correlated with plasma P-selectin level (P <0.01), and positively correlated with HDL-C level (P <0.05). Conclusion Plasma P-selectin and serum NO levels are helpful for the diagnosis of acute coronary syndrome.