论文部分内容阅读
静脉注射大剂量白细胞介素 1 0 (IL- 1 0 )治疗人类炎性肠病有效 ,但因此药可被胃酸破坏 ,故不能口服。比利时根特大学 Steidler等用基因工程技术使非致病性乳酸乳杆菌表达抗炎细胞因子 IL- 1 0 ,此菌可不被胃酸杀死 ,进入结肠把 IL- 1 0直接释放到炎症部位 ,从而可减少 IL- 1
Intravenous injection of large doses of interleukin 10 (IL-10) is effective in treating human inflammatory bowel disease, but the drug can be destroyed by stomach acid and therefore can not be orally administered. Belgium Gent University, Steidler and other genetically engineered technology to make non-pathogenic Lactobacillus lactis expression of anti-inflammatory cytokines IL-10, the bacteria can not be killed by gastric acid into the colon to IL-10 directly to the inflammation site, thus Can reduce IL-1