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延胡索酸(fumaric acid,FA)是荠菜Capsella bursa-pastoris的有效成分,已有报道FA具有抑制小鼠移植性Ehrlich肿瘤、大鼠胃溃疡及硫乙酰胺(TAA)诱发的大鼠肝癌的作用,TAA是有效的肝癌诱发剂,但对诱发小鼠肝癌的报道则甚少,本文即研究了FA对丁AA诱发的小鼠肝癌的抑制作用。结果表明,对照组24只小鼠中,11只发展为肝瘤;若用组织学方法评定,全部被诊断为肝细胞癌;此外有两只小鼠为肝硬化,FA组15只小鼠中,全部无肝癌发生,但有两只动物肝细胞增生,一只动物肝硬化,其它未见
Fumaric acid (FA) is an effective component of Capsella bursa-pastoris. It has been reported that FA has the effect of inhibiting transplanted Ehrlich tumor, rat gastric ulcer and thioacetamide (TAA) induced rat liver cancer. TAA It is an effective hepatoma inducer, but there are few reports on the induction of hepatocarcinogenesis in mice. This article investigated the inhibitory effect of FA on the hepatoma in mice induced by DPA. The results showed that 11 out of the 24 mice in the control group developed liver tumors; if assessed by histological methods, all were diagnosed as hepatocellular carcinoma; in addition, two mice were cirrhotic and 15 in the FA group. No liver cancer occurred, but there were two animal hepatocyte hyperplasias, one animal liver cirrhosis, others