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目的观察缬沙坦治疗扩张型心肌病(DCM)的效果。方法将88例DCM患者随机分为治疗组和对照组各44例。对照组予以休息、低盐饮食、营养心肌、利尿剂、洋地黄、β-受体阻滞剂等常规治疗,治疗组在此基础治疗上给予缬沙坦80mg,1次/d,2周后逐渐加量至160mg,1次/d。治疗60个月后比较两组患者心功能变化及临床疗效。结果两组治疗前后超声心动图结果见表1。两组治疗后心功能较治疗前均明显改善(P<0.05);治疗组心功能较对照组改善明显,差异有统计学意义(P<0.05)。治疗组总有效率(86.4%)高于对照组(68.2%),两组比较,差异有统计学意义(P<0.05)。结论常规治疗基础上加用缬沙坦治疗DCM可明显改善患者临床症状、左室收缩及舒张功能,疗效确切。
Objective To observe the effect of valsartan on dilated cardiomyopathy (DCM). Methods 88 patients with DCM were randomly divided into treatment group and control group, 44 cases each. The control group was given routine treatment such as rest, low-salt diet, nourishing the myocardium, diuretic, digitalis and β-blockers. The treatment group was given valsartan 80mg once a day for 2 weeks Gradually increase the amount to 160mg, 1 time / d. After 60 months of treatment, the changes of cardiac function and clinical efficacy were compared between the two groups. Results before and after treatment echocardiography results in both groups in Table 1. The cardiac function of the two groups was significantly improved after treatment (P <0.05). The cardiac function of the treatment group improved significantly compared with the control group (P <0.05). The total effective rate (86.4%) in the treatment group was higher than that in the control group (68.2%). There was significant difference between the two groups (P <0.05). Conclusion The addition of valsartan to conventional treatment can significantly improve clinical symptoms, left ventricular systolic and diastolic function, with definite effect.