论文部分内容阅读
目的探讨采用不同免疫原的淋巴细胞进行主动免疫治疗原因不明复发性流产(unexplained RSA,URSA)的安全性和有效性。方法选择1995年1月至2006年12月在上海交通大学医学院附属仁济医院就诊260例URSA患者进行主动免疫治疗,免疫原根据临床情况采用三种:丈夫的淋巴细胞、男性或女性无关第三个体的淋巴细胞。结果除外胚胎绒毛染色体异常的病例(10例)所得纠正妊娠成功率:接受丈夫的淋巴细胞成功率为87.28%(151/173);接受男性无关第三个体淋巴细胞为75.81%(47/62);接受女性无关第三个体淋巴细胞为86.67%(13/15)。三者比较差异无统计学意义(P>0.05)。总成功率为84.40%(211/250),同时采用三种免疫原免疫均未见明显副反应。结论对URSA患者采用不同免疫原的淋巴细胞进行主动免疫,具有相似的疗效和安全性。
Objective To investigate the safety and efficacy of active immunotherapy for unexplained recurrent spontaneous abortion (URSA) with lymphocytes of different immunogens. Methods From January 1995 to December 2006, 260 patients with URSA were treated in Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The immunogen was administered according to the clinical situation. There were three kinds of immunogen: husband’s lymphocyte, male or female unrelated Three-body lymphocytes. Results Excluding the cases of chromosomal abnormalities of embryo villi (10 cases), the success rate of correcting pregnancy was 87.28% (151/173), 75.81% (47/62) for accepting husband unrelated third lymphocytes, ; Third female unrelated lymphocytes was 86.67% (13/15). There was no significant difference between the three (P> 0.05). Assembly success rate was 84.40% (211/250), while using the three immunization immunization were no significant side effects. Conclusions Active immunization of lymphocytes from patients with URSA using different immunogens has similar efficacy and safety.