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容量负荷过重是诱发心肌肥厚与心衰的重要原因之一，反之，心肌肥厚与心衰的严重程度亦可间接反映体内容量超负荷增加的程度。研究这一病理生理变化最常用的实验模型是行传统的大鼠下腔静脉—腹主动脉造瘘术，其手术难度大，瘘口口径不均，致使容量超负荷之程度难以掌握，死亡
Volume overload is induced cardiac hypertrophy and heart failure, one of the important reasons, on the contrary, the severity of cardiac hypertrophy and heart failure can indirectly reflect the extent of the increase in the volume of the body overload. The most commonly used experimental model for the study of this pathophysiological change is the conventional rat inferior vena cava-abdominal aortic ostomy. It is difficult to operate and the diameter of the fistula is not uniform, which makes it difficult to grasp the degree of volume overload.