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目的:观察地诺前列酮栓(欣普贝生)与催产素、米索前列醇对促宫颈成熟的效果及对分娩结局的影响。方法:将273例过期妊娠患者分为欣普贝生组(简称观察组)、催产素组(对照1组)及米索前列醇组(对照2组),观察各组的促宫颈成熟及分娩结局。结果:观察组12 h内促宫颈成熟的有效率是90.11%,高于对照1组的78.02%和对照2组的80.22%,差异有显著性(χ2=4.16,P<0.05)。观察组不论是用药至临产时间,还是产程均低于对照1组和对照2组,差异有显著性(χ2=3.84,P<0.05;χ2=4.30,P<0.05);引产成功率则显著优于对照1组和对照2组,差异有极显著性(χ2=9.53,P<0.01)。分娩方式3组之间未见明显差异(χ2=1.02,P>0.05)。结论:欣普贝生可有效促宫颈成熟,引产效果较好,可减少不必要的剖宫产。
Objective: To observe the effect of dinoprostone suppository (Xin P bei sheng) and oxytocin and misoprostol on cervical ripening and its effect on delivery outcome. Methods: A total of 273 cases of obstetric patients were divided into three groups: Enbuthibone group (observation group), oxytocin group (control group 1) and misoprostol group (control group 2) ending. Results: The effective rate of cervical ripening in observation group within 12 h was 90.11%, which was higher than 78.02% in control group 1 and 80.22% in control group 2 (χ2 = 4.16, P <0.05). There was significant difference between the observation group and the control group 1 and control group (χ2 = 3.84, P <0.05; χ2 = 4.30, P <0.05), and the success rate of induction of labor was significantly superior There was a significant difference between control group 1 and control group 2 (χ2 = 9.53, P <0.01). There was no significant difference in mode of delivery between the three groups (χ2 = 1.02, P> 0.05). Conclusion: Enxhiban can effectively promote cervical ripening, induction of labor is better, can reduce unnecessary caesarean section.