本文报告了8例冷球蛋白血症。2例为原发性,6例继发于盘形红斑狼疮、肝吸虫病、自身免疫性溶血性贫血和结节性非化脓性脂膜炎等。5例发作与季节明显相关,表现为冬重夏轻。8例患儿外周血均测得冷球蛋白,血清Ig水平多有增高。重点报告了一例典型病例。介绍了冷球蛋白的测定方法。结合病例讨论了冷球蛋白的分型、发病机理、临床表现、诊断和治疗。 This article reports 8 cases of cryoglobulinemia. 2 were primary and 6 were secondary to discoid lupus, hepatic trematode, autoimmune hemolytic anemia and nodular non-suppurative panniculitis. 5 cases of seizures and the season was significantly related to the performance of winter, summer and summer light. 8 cases of children were measured in the peripheral blood cryoglobulins, serum Ig levels were increased. A typical case was highlighted. The method of determination of cold globulin was introduced. The types, pathogenesis, clinical manifestations, diagnosis and treatment of cryoglobulins were discussed in combination with the cases.