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目的:探讨血清胱抑素C、血清肌酐和尿β2-微球蛋白检测对高尿酸血症肾损害早期诊断的临床价值,为高尿酸血症肾损害的早期诊断提供有效的科学依据。方法:选择70例高尿酸血症患者和70例健康体检者,测定并进行比较。结果:高尿酸血症患者血清胱抑素C、尿β2-微球蛋白与对照组间差异有统计学意义(P<0.05),而传统的肾功指标血肌酐Scr与对照组差异无统计学意义(P>0.05)。结论:血清胱抑素C是一种反映肾小球滤过功能较敏感的指标,对早期发现肾功能的改变,评价病情的发展有重要的作用。
Objective: To investigate the clinical value of serum cystatin C, serum creatinine and urinary β2-microglobulin in the early diagnosis of hyperuricemia and renal damage, and to provide an effective scientific basis for the early diagnosis of hyperuricemia and renal damage. Methods: 70 patients with hyperuricemia and 70 healthy subjects were selected, measured and compared. Results: The serum cystatin C and urinary β2-microglobulin in patients with hyperuricemia were significantly different from those in the control group (P <0.05). However, there was no significant difference between the traditional renal function indicators of serum creatinine Scr and the control group Significance (P> 0.05). Conclusion: Serum cystatin C is a sensitive indicator of glomerular filtration function. It plays an important role in the early detection of changes in renal function and evaluation of the development of the disease.