目的研究人类免疫缺陷病毒(HIV)阳性患者口腔疣状肿块p53、Ki-67、Rb、p16和周期素D1的蛋白表达。方法应用免疫组织化学法检测61例HIV阳性患者口腔疣状肿块p53、Ki-67、Rb、p16和周期素D1蛋白表达。结果 61例HIV阳性患者口腔疣状肿块中p53、Ki-67、Rb、p16和周期素D1蛋白表达率分别为11.5%、78.7%、78.7%、27.9%和29.5%,各基因异常表达率均低于口腔鳞状细胞癌(OSCC)。结论多数HIV阳性患者口腔疣状肿块没有OSCC常见的多基因p53、Ki-67、Rb、p16和周期素D1表达异常。 Objective To study the protein expression of p53, Ki-67, Rb, p16 and cyclin D1 in verrucae of patients with positive human immunodeficiency virus (HIV). Methods Immunohistochemistry was used to detect the expression of p53, Ki-67, Rb, p16 and cyclin D1 in oral warts in 61 HIV-positive patients. Results The expression rates of p53, Ki-67, Rb, p16 and cyclin D1 in oral wart mass in 61 HIV-positive patients were 11.5%, 78.7%, 78.7%, 27.9% and 29.5%, respectively Lower than oral squamous cell carcinoma (OSCC). Conclusions Oral verrucous lumps in most HIV-positive patients do not have abnormal expression of p53, Ki-67, Rb, p16 and cyclin Dl in common OSCC.