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作者以前的实验性致癌工作表明某些多环烃和杂环烃类致癌物和/或它们的荧光性代谢物能在靶细胞的胞质和胞核中检测到。本文进一步比较了三种致癌性不同的多环烃的细胞内定位。根据Pullman分类法所使用的苯(α)吡、二苯(α,h)蒽和二苯(α,c)恩的致癌性分别为((?))、((?))和(一),它们在紫外线下均能发出蓝色荧光。将2月令的雌性Wistar大鼠(平均体重为200克)分为一个对照组和三个实验组,每个实验组各自在腹腔内植入上述一种受试物10mg。在不同时间分批处死动物,取肝、脾、肾、肺、胸腺、颌下腺、胰腺、肾上腺、甲
The author’s previous experimental oncogenic work showed that certain polycyclic and heterocyclic hydrocarbon carcinogens and / or their fluorescent metabolites can be detected in the cytoplasm and nuclei of target cells. This article further compares the intracellular localization of three polycyclic hydrocarbons of different carcinogenicity. The carcinogenicity of benzene (α) pyridine, diphenyl (α, h) anthracene and diphenyl (α, c) , They emit blue fluorescence under UV light. Female February rats (average body weight of 200 g) were divided into one control group and three experimental groups, each of which was intraperitoneally implanted with 10 mg of the above test substance. Animals were sacrificed in batches at different times and liver, spleen, kidney, lung, thymus, submandibular gland, pancreas, adrenal gland