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目的探讨川芎嗪对犬急性肺栓塞(APE)后血液流变性的改善作用。方法随机将成年健康杂种犬30只分为对照组和治疗组。复制犬APE模型,治疗组于肺栓塞0.5 h后开始以200 mL/h速度静滴川芎嗪注射液5 mg/kg(溶于5%葡萄糖注射液中),对照组同时段静滴等量5%葡萄糖注射液。取T1-77个时相,抽静脉血检测全血黏度、还原黏度、红细胞比积、刚性指数及聚集指数等血液流变学指标。结果犬APE后全血黏度及还原黏度明显升高,红细胞比积缓慢增大,红细胞刚性指数和聚集指数升高。川芎嗪注射液可降低全血黏度及还原黏度,对红细胞比积增大、刚性指数和聚集指数的升高有抑制作用。结论犬APE后血液流变学发生变化,川芎嗪可以改善血液流变性指标。
Objective To investigate the effect of ligustrazine on the hemorheology after acute pulmonary embolism (APE) in dogs. Methods 30 healthy adult dogs were randomly divided into control group and treatment group. The model of APE was replicated in the treatment group. The rats in the treatment group started intravenous injection of ligustrazine 5 mg / kg (dissolved in 5% glucose injection) at a rate of 200 mL / h 0.5 h after pulmonary embolism, % Glucose injection. Take T1-77 phase, venous blood pumping blood viscosity, reducing viscosity, hematocrit, rigidity index and aggregation index and other indicators of hemorheology. Results After APE, whole blood viscosity and reducing viscosity were significantly increased, hematocrit slowly increased, erythrocyte rigidity index and aggregation index increased. Ligustrazine injection can reduce whole blood viscosity and reducing viscosity, inhibit the increase of hematocrit, rigidity index and aggregation index. Conclusions The changes of hemorheology in dogs after APE can be observed. Ligustrazine can improve the indexes of hemorheology.