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目的通过超声和肝功能检测探讨苯作业工人非酒精性脂肪肝与颈动脉粥样硬化及肝功能的关系。方法选取深圳市龙岗区内215名工龄在2~18 a的苯作业工人的肝、颈动脉超声及肝功能检查结果进行分析。结果与正常肝对照组比较,中、重度非酒精性脂肪肝组颈动脉内-中膜厚度(IMT)增厚(P<0.01),重度组颈动脉斑块检出率增高(P<0.01),轻度组肝功能丙氨酸氨基转移酶(ALT)异常检出率增高(P<0.05),差异均有统计学意义。在非酒精性脂肪肝组颈动脉内膜增厚检出率及ALT异常检出率,中度组高于轻度组,重度组高于中度组,差异均有统计学意义(P<0.05)。结论苯作业人群中,不同程度非酒精性脂肪肝与颈动脉粥样硬化和肝功能存在相关性。中、重度非酒精性脂肪肝工人更易发生颈动脉粥样硬化,应进行必要的预防和治疗。超声检测颈动脉IMT和肝功能可以反映苯作业人群非酒精性脂肪肝的严重程度,可辅助分级。
Objective To investigate the relationship between non-alcoholic fatty liver disease and carotid atherosclerosis and liver function in benzene workers by ultrasound and liver function tests. Methods The liver, carotid artery ultrasound and liver function tests of 215 workers aged 2-18 years in Longgang District of Shenzhen City were selected. Results Compared with the normal control group, carotid intima - media thickness (IMT) was increased in moderate and severe nonalcoholic steatohepatitis (P <0.01) and carotid plaque was detected in severe group (P <0.01) (P <0.05), the difference was statistically significant. In the non-alcoholic fatty liver group, the carotid artery intimal thickening detection rate and ALT abnormality detection rate were higher in the moderate group than in the mild group and in the severe group than in the moderate group (P <0.05 ). Conclusion There is a correlation between non-alcoholic fatty liver disease and carotid atherosclerosis and liver function in benzene-operated population. Moderate and severe nonalcoholic fatty liver disease more susceptible to carotid atherosclerosis, the necessary prevention and treatment should be carried out. Ultrasound detection of carotid artery IMT and liver function can reflect the severity of non-alcoholic fatty liver in benzene workers can be assisted grading.