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目的研究传染性单核细胞增多症(IM)患儿细胞免疫功能动态变化及其临床意义。方法采用ELISA法和流式细胞仪分别检测了38例生长发育正常的IM患儿急性期和恢复期血清IL-6、IL-8和外周血T淋巴细胞亚群,并与36例同龄健康儿童组比较。结果急性期IM患儿血清IL-6、IL-8、CD3、CD8明显高于对照组及恢复期(P<0.01),CD4、CD4/CD8比值明显低于对照组及恢复期(P<0.01),恢复期患儿血清CD4升高,IL-6、IL-8、CD3、CD8降低,与对照组比较无显著性差异(P>0.05),CD4/CD8比值仍低于对照组(P<0.05),但高于急性期(P<0.01)。结论 EB病毒感染后机体细胞免疫功能异常是IM发病的关键,为IM患儿的免疫治疗提供了理论依据。
Objective To study the dynamic changes of cellular immunity in children with infectious mononucleosis (IM) and its clinical significance. Methods Serum levels of IL-6, IL-8 and peripheral blood T-lymphocyte subsets in 38 normal-growth and normal IM infants were detected by ELISA and flow cytometry in 38 children with normal development and 36 healthy children of same age Group comparison. Results The serum levels of IL-6, IL-8, CD3 and CD8 in children with acute IM were significantly higher than those in control group and convalescent stage (P <0.01), while the ratios of CD4 and CD4 / CD8 were significantly lower in control group and recovery stage (P <0.05). The CD4 / CD8 ratio was still lower in the convalescence children than in the control group (P < 0.05), but higher than the acute phase (P <0.01). Conclusion The abnormal cellular immune function after EBV infection is the key to the pathogenesis of IM, which provides a theoretical basis for the immunotherapy of children with IM.