以3-氰基-5-乙酰基-6-甲基吡啶-2-酮(1a～1b)为原料,通过多步反应,合成了18种未见报道的含有均三唑并[3,4-b][1,3,4]噻二嗪或1,3,4-噁二唑啉的两类新型吡啶酮类化合物4a～4h,7a～7j,其结构经1H NMR,IR和MS及元素分析确证.利用单晶X射线衍射法测定了化合物4a的晶体结构.初步生测表明,部分化合物表现出不同的抗菌活性. A total of 18 unreported compounds were synthesized from 3-cyano-5-acetyl-6-methylpyridin-2-one (1a ~ 1b) -b] [1,3,4] thiadiazoles or 1,3,4-oxadiazolines. Their structures were confirmed by 1H NMR, IR and MS and Elemental analysis confirmed that single crystal X-ray diffraction method was used to determine the crystal structure of compound 4a.The preliminary bioassay indicated that some of the compounds showed different antibacterial activities.