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中药有效成分保护心肌缺血再灌注作用包括了清除自由基、抑制钙超载、促进血管新生、抑制炎症损伤等方面,通过这些方面的作用增强心肌细胞抗损伤能力,促进机体生成具有保护心肌作用的物质,改善缺血缺氧心肌细胞的代谢状态。通过查询近年来抗心肌缺血再灌注损伤的相关文献,总结了近年来干预心肌细胞缺血再灌注损伤效果明显的多种中药组分以及其对心肌再灌注损伤作用机制研究概况。本文就中药有效成分抗心肌缺血再灌注损伤的相关机制进行综述。
The active ingredients of Chinese medicine protect myocardium against ischemia-reperfusion, including scavenging free radicals, inhibiting calcium overload, promoting angiogenesis, and inhibiting inflammatory damage. Through these aspects, they can enhance the ability of myocardial cells to resist injury and promote the body’s production of myocardial protection. Substances improve the metabolic state of ischemic and hypoxic cardiomyocytes. By referring to the relevant literatures on myocardial ischemia-reperfusion injury in recent years, we summarized recent studies on the effects of various traditional Chinese medicine components that interfere myocardial cell ischemia-reperfusion injury and their mechanisms of myocardial reperfusion injury. This article reviews the mechanism of anti-myocardial ischemia reperfusion injury of active ingredients of traditional Chinese medicine.