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使用ＣＨＩＲＡＬ－ＡＧＰ柱，通过优化色谱条件，以ＨＰＬＣ法对３种手性药物ＳＦＺ－４７〔（±）－３Ｈ－１，２－二氢－２－（４－甲基苯胺基）－甲基－１－吡咯里嗪酮〕，ＫＭＢＺ－００９〔（±）－反式－４－苯基－５－（邻氯苄基）－吡咯烷酮－２〕和地丙苯酮〔（±）－２′－（２－羟基－３－（特戊胺基）丙氧基）－３－苯基苯丙基酮〕进行了对映体的直接分离，达到良好的分离效果．在此基础上测试了动物血浆样品中ＳＦＺ－４７的对映体，对其药物动力学的对映体选择性进行了初步研究．
The chiral drugs SFZ-47 [(±) -3H-1,2-dihydro-2- (4-methylanilino) -methyl Pyrrolizinone], KMBZ-009 [(±) -trans-4-phenyl-5- - (2-hydroxy-3- (amylamido) propoxy) -3-phenylpropyl ketone] direct separation of enantiomers, to achieve good separation. Based on this, the enantiomers of SFZ-47 in animal plasma samples were tested and the enantioselectivity of their pharmacokinetics was studied.