目的调查幽门螺杆菌(HP)感染与不同类型上消化道疾病的相关性,研究HP感染的分布情况,并对HP感染的危险因素进行分析,为临床防治提供依据。方法随机选取2013年5月-2015年7月治疗962例上消化道疾病患者,采用胃镜及病理学方法进行上消化道疾病诊断;以14C尿素呼气试验测为HP感染状况诊断方法,分析不同类型上消化道疾病患者,HP感染率及每位入选患者的基本情况,探究上消化道疾病与HP感染的关系。结果 962例上消化道疾病患者中,HP感染553例,感染率为57.48%;其中25~35岁人群感染率为57.92%,≥65岁年龄段感染率为56.23%,不同上消化道疾病患者中不同年龄段之间行HP感染率组间对比,各组间感染率无明显差异,在上消化道类疾病中,消化性溃疡患者HP检出率94.6%为最高,食管炎患者及胃癌患者HP检出率分别为67.94%、55.26%;慢性胃炎患者HP检出率40.3%最低;HP感染率在饮酒者与无酒嗜好者之间对比,差异有统计学意义(P<0.05);其HP感染率在既往有HP感染病史与既往无HP感染病史者之间比较,差异有统计学意义(P<0.05)。结论 HP感染与上消化道类疾病密切相关,其中以消化性溃疡相关性最大,在临床治疗患者消化道类疾病时需对其给予关注并采取相应的治疗方案。 Objective To investigate the correlation between Helicobacter pylori (HP) infection and different types of upper gastrointestinal diseases and to study the distribution of HP infection and to analyze the risk factors of HP infection so as to provide the basis for clinical prevention and treatment. Methods A total of 962 cases of upper gastrointestinal diseases were treated randomly from May 2013 to July 2015. The upper gastrointestinal diseases were diagnosed by endoscopy and pathology. The 14C urea breath test was used to diagnose the HP infection. Type of upper gastrointestinal disease, HP infection rate and the basic situation of each selected patients to explore the relationship between upper gastrointestinal diseases and HP infection. Results Of the 962 patients with upper gastrointestinal diseases, 553 were infected with HP, the infection rate was 57.48%. Among them, the infection rate was 57.92% in patients aged 25-35 years, and 56.23% in patients aged 65 or older. In different upper gastrointestinal diseases In different age groups between the HP infection rate comparison between the groups, no significant difference in infection rates among groups in the upper gastrointestinal diseases, peptic ulcer patients with the highest detection rate of 94.6%, esophagitis patients and patients with gastric cancer The detection rate of HP was 67.94% and 55.26% respectively. The detection rate of HP was the lowest in 40.3% patients with chronic gastritis. The HP infection rate was significantly different between drinkers and non-alcohol addicts (P <0.05) HP infection rate in the past with HP infection history and previous non-HP infection history comparison, the difference was statistically significant (P <0.05). Conclusion HP infection is closely related to upper gastrointestinal diseases, of which peptic ulcer is the most relevant. In the clinical treatment of patients with gastrointestinal diseases, attention should be paid to them and the corresponding treatment plan should be taken.