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目的探讨肝动脉化疗栓塞联合亚砷酸注射液治疗中晚期肝癌的近期疗效。方法采用羟基喜树碱(HCPT)30 mg+5-Fu 1.0 g+ADM 40 mg+PDD 40 mg灌注化疗,然后将HCPT 10 mg与栓塞剂充分混合后栓塞,间隔4周,2~3个周期后观察疗效。同时给予0.1%亚砷酸注射液15 mL加入生理盐水500 mL中缓慢静滴3 h,每日1次,连用14 d,间隔2周重复。结果共完成治疗84周期,平均2.8周期。在可评价的30例中,总有效率77%。治疗后KPS评分提高20例(67%),稳定7例(23%),下降3例(10%)。不良反应可耐受。结论采用以HCPT为主的TACE联合亚砷酸注射液治疗中晚期原发性肝癌近期疗效较好。
Objective To investigate the short-term curative effect of transcatheter arterial chemoembolization combined with arsenite injection in the treatment of advanced liver cancer. Methods HCPT 30 mg + 5-Fu 1.0 g + ADM 40 mg + PDD 40 mg were used for chemotherapy. After HCPT 10 mg and embolization agent were mixed well, they were embolized at intervals of 4 weeks and 2 to 3 cycles Observed after the effect. At the same time given 0.1% arsenic acid injection 15 mL added 500 mL of normal saline intravenously slowly for 3 h, once daily, once every 14 d, repeated 2 weeks apart. Results A total of 84 cycles were completed, with an average of 2.8 cycles. Of the 30 evaluable cases, the total effective rate was 77%. After treatment, the KPS score increased by 20 cases (67%), stable in 7 cases (23%) and decreased in 3 cases (10%). Adverse reactions are tolerable. Conclusion HCPT-based TACE combined with arsenic acid injection in the treatment of advanced primary liver cancer has a good short-term effect.