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目的分析宫颈上皮内瘤变(CIN)患病危险因素,为CIN和宫颈癌防治提供依据。方法采用病例对照研究方法,在兰溪市妇幼保健计划生育服务中心选取179例CIN患者作为病例组,同期排除CIN的336名正常体检者作为对照组,进行问卷调查并分析CIN患病的危险因素。结果实际回收有效问卷502份,两组对象的年龄、文化程度和婚姻状况比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,多性伴(OR=1.217,95%CI:1.061~1.253)、性伴多性(OR=2.038,95%CI:1.044~3.828)、性接触传播疾病(STD)感染(OR=12.546,95%CI:5.728~17.257)和无保护性行为(OR=1.429,95%CI:1.017~1.293)是CIN患病的独立危险因素。结论多性伴、性伴多性、STD感染和无保护性行为可增加CIN患病风险。应加强生殖健康和安全性行为知识宣传,控制相关危险行为的发生。
Objective To analyze the risk factors of cervical intraepithelial neoplasia (CIN) and provide evidence for CIN and cervical cancer prevention and treatment. Methods A case-control study was conducted in 179 maternal and child care family planning service centers in Lanxi City as the case group and 336 normal subjects who were excluded from CIN as the control group. Questionnaires were conducted and the risk factors of CIN were analyzed. Results There were 502 valid questionnaires actually collected. There was no significant difference in age, education level and marital status between the two groups (P> 0.05). Multivariate logistic regression analysis showed that sexual contact with multiple sex partners (OR = 1.217, 95% CI: 1.061-1.253), multiple sex partners (OR = 2.038, 95% CI: 1.044-3.828), sexually transmitted disease (STD) Infection (OR = 12.546, 95% CI: 5.728-17.257) and unprotected sex (OR = 1.429, 95% CI: 1.017-1.293) were independent risk factors for CIN. Conclusions Multiple sexual partners, multiple sex partners, STD infection and unprotected sex may increase the risk of CIN. Publicity on reproductive health and safety behaviors should be strengthened to control the occurrence of relevant dangerous behaviors.