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目的探讨非小细胞肺癌(NSCLC)患者血清肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、白介素6(IL-6)水平变化及临床意义。方法选取2012年1月—2014年12月陕西中医药大学第二附属医院收治的NSCLC患者58例为病例组,另选取同时期在本院进行体检的健康成年人25例为对照组。检测并比较两组患者的血清TNF-α、IL-1β及IL-6水平。结果病例组患者的血清TNF-α、IL-1β及IL-6水平高于对照组(P<0.05)。临床分期为Ⅳ期NSCLC患者的血清TNF-α、IL-1β及IL-6水平高于Ⅲ期患者,Ⅲ期患者高于Ⅱ期患者(P<0.05)。有淋巴结转移患者的血清TNF-α、IL-1β及IL-6水平高于无淋巴结转移患者(P<0.05)。结论血清TNF-α、IL-1β及IL-6水平升高可能与NSCLC的发生、发展密切相关,检测其血清水平对NSCLC患者的病情监测和预后判断有重要意义。
Objective To investigate the changes of serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin 6 (IL-6) in patients with non-small cell lung cancer (NSCLC) and their clinical significance. Methods Fifty-eight NSCLC patients admitted to the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2012 to December 2014 were selected as the case group. Another 25 healthy adults were selected as the control group during the same period. The levels of serum TNF-α, IL-1β and IL-6 in the two groups were detected and compared. Results The levels of serum TNF-α, IL-1β and IL-6 in the patients were significantly higher than those in the control group (P <0.05). The levels of serum TNF-α, IL-1β and IL-6 in patients with stage Ⅳ NSCLC were higher than those in patients with stage Ⅲ, and those in stage Ⅲ were higher than those in patients with stage Ⅱ (P <0.05). The serum levels of TNF-α, IL-1β and IL-6 in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.05). Conclusion Serum levels of TNF-α, IL-1β and IL-6 may play an important role in the pathogenesis and prognosis of NSCLC. Detecting the serum level of TNF-α, IL-1β and IL-6 in NSCLC patients is of great significance in monitoring the disease and prognosis.