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作者对７６例大肠各型息肉和腺瘤进行了组织形态学观察，对所见灶性异型增生的特征及其意义进行了分析。结果显示，大肠各型息肉灶性异型增生的检出率分别为：炎性息肉１０％，幼年性息肉为零，增生性息肉８．３％，息肉状腺瘤４２．９％，绒毛状腺瘤６６．７％，家族性腺瘤５０％和腺瘤癌变１００％。灶性异型增生细胞位于某一腺管或分支的乳头上，少者仅有２至５个细胞，多者达１０余个细胞。可向管腔内或基底膜外突起，拥挤排列，极向紊乱。细胞体积增大，尤其核增大明显，核染色质粗，可见核仁，有的核形不规则。灶性异型增生同两侧的腺上皮有明显的形态差异，亦可有过渡现象。灶性异型增生ｒａｓ癌基因产物Ｐ２１蛋白表达５９．３％，癌胚抗原７７．８％，ＭＣ３５９．３％，ＰＮＡ受体６３．０％，ＡｇＮＯＲ计数２．８４～８．６１个之间，每个细胞银颗粒超过４个的细胞４７．０５％，一些银颗粒增大，不规则。提示大肠粘膜腺体灶性异型增生是重要的癌前期病变。
The authors carried out histomorphological observations of 76 cases of polyps and adenomas of the large intestine, and analyzed the characteristics and significance of focal dysplasia. The results showed that the detection rate of focal polyps of various types of polyps in the large intestine were: inflammatory polyps 10%, juvenile polyps zero, hyperplastic polyps 8.3%, polypoid adenomas 42.9%, villous glands The tumor was 66.7%, familial adenoma 50%, and adenoma canceration 100%. Focal dysplasia cells are located on the nipples of one gland tube or branch. The few have only 2 to 5 cells and more than 10 cells. Can be protruding into the lumen or basement membrane, crowded arrangement, pole to disorder. The volume of the cells increases, in particular the nucleus increases significantly, the nuclear chromatin is thick, visible nucleoli, and some karyotypes are irregular. Focal dysplasia has obvious morphological differences with glandular epithelium on both sides, and there may also be transitional phenomena. The expression of ras oncogene product P21 protein was 59.3%, carcinoembryonic antigen 77.8%, MC359.3%, PNA receptor 63.0%, and AgNOR count 2.84-8.61. The number of cells with more than 4 silver particles per cell is 47.05%, and some silver particles are enlarged and irregular. It suggests that focal dysplasia of colorectal mucosa is an important precancerous lesion.