~(123)I-邻碘马尿酸(下称~(123)I-OIH)由于(123)I半衰期短、γ射线能量合适、无β射线发射,较之常用的~(131)I-OIH,不仅可使病人接受剂量显著减小,而且成像清晰、可提高诊断的准确性,是目前较理想的肾动态显像剂。 Ellas用熔融法标记~(131)I-间碘马尿酸之后,Westera等制备了~(123)I-OIH。本文旨在以我们自制的~(123)I-碘化钠和OIH为原料,找到一个操作简便、产率高,放化纯度好、工艺稳定、实用性强的快速标记~(123)I-OIH的方法。并进行小鼠体内分布试验以及兔和犬的肾动态γ照相。 Due to the short half-life of (123) I, the γ-ray energy is suitable and there is no β-ray emission compared with the commonly used 131I-OIH , Not only allows patients to receive a significant dose reduction, and imaging clear, can improve the diagnostic accuracy, is the ideal renal dynamic imaging agent. Westera et al. Prepared ~ (123) I-OIH after Ellas labeled ~ (131) I-iodohippuric acid by melt method. The purpose of this paper is to find a fast labeled ~ (123) I-H20 with simple, high yield, good radiochemical purity, stable process and high practicability from our homemade ~ (123) I-sodium iodide and OIH. OIH method. In vivo distribution experiments were performed in mice as well as renal dynamic gamma photography in rabbits and dogs.