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为探讨有氧运动训练对大鼠下丘脑食欲调节肽的影响，实验选用Ｗｉｓｔａｒ雄性成年大鼠３６只，体重１９５ｇ±１０ｇ，随机分为正常对照组和运动组。运动组每天游泳６０分钟，每周６天，连续训练６周。记录实验开始及结束时动物体重。测定内脏附睾脂肪垫、血Ｌｅｐｔｉｎ及下丘脑ＮＰＹ、ＧＡＬ、ＣＣＫ、ＢＮ水平和下丘脑弓状核ＮＰＹ基因表达的非同位素原位分子杂交结果。结果表明：有氧运动可导致内脏附睾脂肪垫降低、体重减轻。这可能是长期有氧运动升高血浆Ｌｅｐｔｉｎ水平，Ｌｅｐｔｉｎ作用于下丘脑，抑制下丘脑ＮＰＹ的基因表达，调控ＮＰＹ的转录水平，从而使下丘脑ＮＰＹ蛋白合成减少，机体产热增加，能量消耗增多。另外，长期有氧运动后下丘脑饱食因子ＣＣＫ水平显著增加。食欲调节因子综合作用的结果，可能是长期有氧运动内脏脂肪垫降低、体重减轻的重要原因。
In order to investigate the effect of aerobic exercise on hypothalamic appetite regulating peptide in rats, 36 Wistar male adult rats weighing 195 g ± 10 g were randomly divided into normal control group and exercise group. Exercise group swimming 60 minutes a day, 6 days a week, continuous training for 6 weeks. Animal weight was recorded at the beginning and at the end of the experiment. The visceral epididymal fat pad, blood Leptin and hypothalamus NPY, GAL, CCK, BN levels and hypothalamic arcuate nucleus NPY gene expression of non-isotope in situ hybridization results. The results showed that: aerobic exercise can lead to lower visceral epididymal fat pad, weight loss. This may be the long-term aerobic exercise increased plasma Leptin levels, Leptin in the hypothalamus, inhibiting hypothalamic NPY gene expression, regulating NPY transcriptional level, so that hypothalamic NPY protein synthesis decreased body heat production, increased energy consumption . In addition, the CCK level of hypothalamic satiety factor increased significantly after long-term aerobic exercise. The result of the combined action of the appetite regulating factor may be the important reason for the reduction of visceral fat pad and weight loss in long-term aerobic exercise.