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急性高原病(AMS)的发病机制迄今仍尚不十分清楚,曾提出过各种假说,但仍缺乏充分的动物实验和人体观察的科学数据给予确证。本研究室的动物实验与人体低压舱实验和高原现场观察结果表明,1.AMS的发生与动脉血氧分压(PaO_2)的降低程度和肺泡与动脉血氧梯度差(AaDO_2)的增大有关,肺泡表面活性物质的代谢过程和活性降低而影响肺泡壁氧的弥散,可能在其中起一定作用.2.体液转运失调是AMS发病机制中的重要环节.低压舱人体实验表明,急性低氧暴露时,未患
The pathogenesis of acute mountain sickness (AMS) remains unknown to date, and various hypotheses have been proposed but scientific data lacking adequate animal experiments and human observations are corroborated. The animal experiments in our laboratory and the human body in the hypoxia chamber experiments and the observation of the plateau site showed that 1. The occurrence of AMS was related to the decrease of PaO_2 and the increase of the alveolar and arterial oxygen gradient (AaDO_2) , Alveolar surfactant metabolism and activity decreased affect the proliferation of alveolar wall oxygen may play a role in them.2 The imbalance of body fluid transport is an important part of the pathogenesis of AMS Low pressure cabin human experiments show that acute hypoxia exposure When, not suffering