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迄今已有不同HbA_1c切点值被建议用于糖尿病筛查,然而特别是对不同种族还需要更被公认的HbA_1c最佳值。我们在基于人群的前瞻性队列研究中,评估了HbA_1c水平对未诊断的糖尿病筛查,以及对6年糖尿病发病率预测的作用。研究者从Ansung-Ansan队列研究中共计纳入10038例患者。所有受试者在基线时和随访期间每两年均接受75g口服葡萄糖耐量试验。排除有糖尿病史的患者(n=572),采用受试者工作特征曲线评估HbA_1c切点值的诊断准确性,采用Cox比例风险模型预测第6年的糖尿病发生。
To date, different HbA_1c cutoff values have been suggested for diabetes screening, however, the best known value of HbA_1c is needed for different races. In a population-based, prospective cohort study, we assessed the impact of HbA 1c levels on undiagnosed diabetes screening and on the prediction of 6-year diabetes prevalence. The researchers enrolled 10,038 patients from the Ansung-Ansan cohort study. All subjects received a 75 g oral glucose tolerance test every two years during baseline and follow-up periods. Patients with a history of diabetes were excluded (n = 572). The diagnostic accuracy of the HbA 1 c cutoff value was evaluated using the receiver operating characteristic curve and the 6-year incidence of diabetes was estimated using the Cox proportional hazard model.