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目的:观察赖诺普利与卡托普利改善糖尿病性心肌病患者心功能的比较研究。方法:对66例患者随机分为治疗组(36例),对照组(30例),治疗组在常规强心基础上加用赖诺普利5～10 mg·d~(-1),对照组用卡托普利25 mg,tid,6～12个月后采用超声心动图进行对比观察。结果:治疗组反映左室形态、收缩、舒张功能的指标明显改善(P<0.05,P<0.01),对照组部分指标有改善,治疗组总有效率为86.1％,对照组76.67％,治疗组病死率为2.78％,对照组病死率16.67。结论:糖尿病性心肌病患者加用赖诺普利,不仅能改善左室收缩,舒张功能及左室形态,并且降低病死率。
Objective: To observe the comparison of heart function between lisinopril and captopril in patients with diabetic cardiomyopathy. Methods: 66 patients were randomly divided into treatment group (36 cases) and control group (30 cases). The treatment group was treated with lisinopril 5 ~ 10 mg · d ~ (-1) Group captopril 25 mg, tid, 6 to 12 months after the use of echocardiography comparative observation. Results: The left ventricular morphology, the index of systolic and diastolic function in the treatment group were significantly improved (P <0.05, P <0.01), and some indicators in the control group were improved. The total effective rate was 86.1% in the treatment group and 76.67% in the control group. The case fatality rate was 2.78% and the control group was 16.67. Conclusions: The addition of lisinopril in patients with diabetic cardiomyopathy can not only improve left ventricular systolic and diastolic function and left ventricular morphology, but also reduce mortality.